General Information

  • ID:  hor001081
  • Uniprot ID:  NA
  • Protein name:  QDPFLRF-amide
  • Gene name:  NA
  • Organism:  Hirudo medicinalis
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  QDPFLRF
  • Length:  7
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Controll pharyngeal motility
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001081_AF2.pdbhor001081_ESM.pdb

Physical Information

Mass: 102925 Formula: C44H63N11O11
Absent amino acids: ACEGHIKMNSTVWY Common amino acids: F
pI: 6.34 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 3
Hydrophobicity: -52.86 Boman Index: -1830
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: 9111.43 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12491073
  • Title:  Regulation of Pharyngeal Motility by FMRFamide and Related Peptides in the Medicinal Leech, Hirudo Medicinalis